DRUG-INDUCED SMOOTH MUSCLE CONTRACTION WITH NO CHANGE IN THE LEVEL OF CYCLIC GMP
نویسندگان
چکیده
منابع مشابه
Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle.
The potent vasodilator action of cyclic GMP-dependent protein kinase (cGK) involves decreasing the Ca(2+) sensitivity of contraction of smooth muscle via stimulation of myosin light chain phosphatase through unknown mechanisms (Wu, X., Somlyo, A. V., and Somlyo, A. P. (1996) Biochem. Biophys. Res. Commun. 220, 658-663). Myosin light chain phosphatase activity is controlled by the small GTPase R...
متن کاملMechanism of cyclic-GMP-dependent relaxation in vascular smooth muscle.
Marston, S. B. & Smith, C. W. J. (1984)J. Muscle Res. 5,559-575 Marston. S. B. & Smith, C. W. J. (1 985) J. Muscle Res. 6,669-708 Marston, S. B., Lehman, W., Moody. C. & Pritchard, K. ( 1 988) in Calcium and Calcium binding Proteins (Gerday, C., Gilles, R. & Bolis, L., eds.). pp. 69-8 1, Springer Verlag, Heidelberg Mathew, J. K., Krolak, J. M. & Dedman, J. R. ( 1 986) J. Cell. Biochem. 32,223-2...
متن کاملRegulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase.
This basic science review examines the role of cGMP and cGMP-dependent protein kinase (PKG) in the regulation of vascular smooth muscle cell (VSMC) phenotype. The first such studies suggested a role for nitric oxide (NO) and atrial natriuretic peptides (ANP), and the downstream second messenger cGMP, in the inhibition of VSMC proliferation. Subsequently, many laboratories confirmed the anti-pro...
متن کاملCyclic AMP modulation of adrenoreceptor-mediated arterial smooth muscle contraction
We examined the effects of cyclic AMP (cAMP) on the intracellular Ca2+ release in both the intact and skinned arterial smooth muscle. The amount of Ca2+ in the sarcoplasmic reticulum (SR) was estimated indirectly by caffeine-induced contraction of the skinned preparation and directly by caffeine-stimulated 45Ca efflux from the previously labeled skinned preparation. The norepinephrine-induced r...
متن کاملPreventive effects of ipratropium and salbutamol against insulin induced tracheal smooth muscle contraction in guinea pig model
Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1976
ISSN: 0021-5198
DOI: 10.1254/jjp.26.501